A thiirane linker for isopeptide mimetics by peptide ligation

Peptide ligation catalyzed by functionalized gold nanoparticles.

Towards Synthetic Peptide Ligation

Phosphate-assisted peptide ligation.

A novel ligation method for the synthesis of phosphopeptides and peptides is described, which utilises the inherent reactivity of a peptide bearing an N-terminal phosphoserine or phosphothreonine residue to facilitate amide bond formation with a range of C-terminal peptide thioesters.

A General Chemical Ligation Approach Towards Isopeptide-Linked Ubiquitin and Ubiquitin-Like Assay Reagents

Ubiquitin (Ub) and ubiquitin-like proteins (Ubls) form a family of small and highly conserved post-translational modifiers that become linked to target proteins and thus modulate their function (such as degradation, trafficking and signalling). The linkage between a Ub(l) and a target protein most frequently consists of an isopeptide bond between the C-terminal carboxylate of Ub(l) and the e-am...

Enzymatic Macrocyclization of 1,2,3‐Triazole Peptide Mimetics

The macrocyclization of linear peptides is very often accompanied by significant improvements in their stability and biological activity. Many strategies are available for their chemical macrocyclization, however, enzyme-mediated methods remain of great interest in terms of synthetic utility. To date, known macrocyclization enzymes have been shown to be active on both peptide and protein substr...